Hypertension Essay -- Health, Cardiovascular Diseases, Stroke

high blood pressure is one of the major risk factors for the development of cardiovascular diseases including stroke and face cloththorn also render a region in the development of vascular cognitive impairment and vascular dementia 1, 2. Angiotensin I-converting enzyme (EC 3.4.15.1 ACE) plays an important role in the rennin- angiotonin system and it is a carboxyl-terminal dipeptidyl exopeptidase that catalyzes the conversion of angiotensin I to angiotensin II 3-6. ACE converts an inactive form of decapeptide, angiotensin I, to a starchy vasoconstrictor, octapeptide, angiotensin II, in addition since the ACE is a multifunctional enzyme it also catalyzes the abjection of bradykinin, which is known as a vasodilator 4, 7. Therefore, inhibition of ACE legal action leads to decrease in the concentration of angiotensin II and increases the level of bradykinin so reduce blood pressure 8. The disco real of captopril as a potent inhibitor of ACE led to the recent development of many s erial publication of novel structures with similar biological activity 9. To date a unspecific variety of ACE inhibitors from various land and marine nutrition sources have been reported such as milk 10, cheese 11, egg white 12, canola 13, peanut 14, rapeseed 15, antler 16, fish muscle 17, seaweeds 18 and tuna 2. Many academic, scientific, and regulatory organizations argon considering ways to establish the scientific basis to support and further bear out claims for functional components or the foods containing them. Consumer enliven in the relationship between food and health has increased the demand for information about functional foods. more(prenominal) recently, the food industry, the agricultural community, and now consumers have shown a growing interest in the field of... ...dependent on the conversion of yellow tetrazolium bromide to its purpleness formazan derivative by mitochondrial succinate dehydrogenase in viable cells 34. In conclusion, E. cava is a very interes ting resource, due to the presence of unique phlorotannin derivatives with special bioactivities including ACE inhibitory activity. Ethanol enhances the extraction of phlorotannins specially dieckol from the brown seaweed E. cava. By contrast, in this con phloroglucinol derivative dieckol exhibited the strongest activity against ACE. With the results of this study we can suggest that the brown seaweed E. cava could be used in development of promising and potential functional food products. Moreover, it is expected that these findings will contribute to developing interests in basic inquiry and potential applications of the phlorotannins in the relevant fields.